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血清纤维细胞生长因子21是慢性肝病中缓冲症的一个新生物标志物

Takatsugu Tanaka¹, Goki Suda¹, Masatsugu Ohara¹

¹Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Frontiers in nutrition

|March 6, 2026

概括

血清FGF21是慢性肝病 (CLD) 中缓冲症的关键预测因子. 这种生物标志物可以帮助识别有风险的患者,以便及时进行干预并改善结果.

科学领域:

肝病学肝病学是一种肝病学.
生物标志物发现发现
临床医学临床医学

背景情况:

长期性肝病 (CLD) 的预后明显恶化.
在CLD患者中,缓解症的预测因子并未得到很好的定义.
这项研究旨在确定临床和血清生物标志物在CLD中预测缓冲症的预测因素.

研究的目的:

调查与患有CLD的患者中卡赫克西亚相关的临床因素和血清生物标志物.
为了确定在CLD中缓解症的独立预测因子.
评估血清生物标志物的有用性,包括FGF21,IL-6和TNF-α,用于预测缓冲症.

主要方法:

对356名CLD患者的分析,包括完整的缓解症评估和血清样本.
在发现队列中测量了血清纤维细胞生长因子21 (FGF21),干白素-6 (IL-6) 和瘤亡因子-α (TNF-α).
应用多变量逻辑回归和ROC分析,在一个独立的队列中验证.

主要成果:

在24.6%的患者中出现了尾症,并且独立地预测了更差的存活率.
在卡赫西亚患者 (292 pg/mL与177 pg/mL) 中观察到较高的血清FGF21度.
血清FGF21是缓解症的唯一独立生物标志物预测因子;高级的Child-Pugh类和血小板计数也是显著的预测因子.

结论:

血清FGF21独立地预测了CLD患者的缓解症.
FGF21可能有助于早期识别患有缓冲症风险的患者.
早期识别可以促进及时干预,以改善CLD的临床结果.

关键词:

生物标志物生物标志物卡赫西亚 (Cachexia) 是一种缓解症.慢性肝脏疾病慢性肝脏疾病纤维细胞生长因子的成长因子肝硬化是肝硬化的一种疾病.

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