美国和阿联成年人呼吸道微生物群与喘的关联:比较分析
Ariangela J Kozik1, Kyra Henderson1, Laila Salameh2
1Department of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
概括
在不同地理区域内,下呼吸道微生物群的喘相关差异仍然存在. 吸入性皮质类固醇使用和肥胖等临床因素显著影响喘患者的呼吸道微生物群组成.
科学领域:
- 微生物学 微生物学
- 肺部医学 肺部医学
- 基因组学就是基因组学.
背景情况:
- 喘的临床特征与下呼吸道微生物组的变化有关.
- 有限的数据存在于与喘相关的气道微生物群差异的地理影响和人口相似性.
研究的目的:
- 调查气道微生物群的组成是否在不同地理区域之间存在差异.
- 为了确定与喘相关的下呼吸道微生物群的差异是否在不同种群中一致.
主要方法:
- 重新处理了来自美国和阿联队伍的患有或没有喘的成年人吐中的16S rRNA基因序列数据.
- 利用合并计算分析来检查与研究地点,喘状况,吸入性皮质类固醇 (ICS) 使用和肥胖相关的差异.
主要成果:
- 唾液的细菌组成因研究地点而异,但在两个队列中都观察到与喘相关的差异.
- 与未接受ICS治疗的患者相比,接受ICS治疗的喘患者的细菌基因多样性减少 (p = 0.006).
- 肥胖状况影响了唾液细菌组成 (p = 0.004),在肥胖个体中丰富了Rothia和Veillonella等特定属的细菌组成.
结论:
- 在喘中影响下呼吸道微生物群的临床因素似乎超越了地理差异.
- 研究结果强调了ICS治疗和肥胖在塑造喘中呼吸道微生物群中的作用.
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