巨的歌剧:从代谢前奏到瘤性升在代谢功能障碍相关的脂肪性肝病
1Clinical Medicine, School of Basic Medical Sciences, Naval Medical University, Shanghai, China.
Frontiers in medicine
|March 6, 2026
概括
肝脏巨细胞驱动了与代谢功能障碍相关的脂肪性肝病 (MASLD) 进展到癌症. 针对这些巨细胞为MASLD,代谢功能障碍相关的脂肪肝炎 (MASH) 和肝细胞癌 (HCC) 提供了新的治疗策略.
科学领域:
- 肝病学和免疫学 肝病学和免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 和其炎症形式,代谢功能障碍相关的脂肪性肝炎 (MASH),正在引起全球健康问题的日益增加.
- 这些情况可以发展为肝硬化,并增加肝细胞癌 (HCC) 的风险.
- 在这种疾病谱中,肝细胞巨细胞是启动,进展和恶性转变的核心.
研究的目的:
- 系统地审查MASLD,MASH和HCC中的巨细胞中心机制.
- 评估当前和新兴的向巨细胞的治疗策略.
- 强调了解巨细胞动态对于有效干预的重要性.
主要方法:
- 对MASLD-MASH-HCC中肝脏巨细胞的当前文献进行系统审查.
- 划分巨细胞的起源,异质性,可塑性和结构.
- 阐明特定阶段的巨细胞驱动机制和治疗方法.
主要成果:
- 肝细胞巨体表现出M1/M2以外的多样化表型,影响疾病的进展.
- 机制包括脂毒性压力,库普费尔细胞招募和与疾病相关的巨细胞子集的形成.
- 巨驱动的过程创造了一个免疫抑制的瘤微环境,导致HCC的治疗耐药性.
结论:
- 了解肝脏巨细胞的时空动态对于MASLD-MASH-HCC进展至关重要.
- 针对巨细胞的招募,两极分化,新陈代谢和功能,有望为新型疗法提供希望.
- 以巨细胞为中心的特定阶段干预是阻止疾病进展和改善患者存活率的关键.
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