调整低剂量阿司匹林以预防妊娠前:转化和生物标志物见解
1Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Frontiers in medicine
|March 6, 2026
概括
低剂量阿司匹林有助于预防高风险怀孕中的孕前. 然而,指导阿司匹林使用的生物标志物仍在研究中,尚未推用于临床实践.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 低剂量阿司匹林是高风险怀孕中产前的唯一已确定的药理预防措施.
- 对阿司匹林个体反应的显著变异性需要探索生物标志物,以了解阿司匹林反应性和产前异质性.
研究的目的:
- 审查和综合当前关于遗传,血小板和血管原生生物标志物的文献,用于产前的阿司匹林预防.
- 提供关于这些生物标志物的现有证据的概念概述.
主要方法:
- 采用了叙事审查方法.
- 在主要的生物医学数据库中进行了有针对性的文献搜索.
- 包括翻译,观察和临床研究.
主要成果:
- 遗传变异,血小板指数和血管原生生物标志物 (例如,sFlt-1,plgf) 已被探索,以改进风险分层并解释阿司匹林反应的变化.
- 目前对遗传和血小板生物标志物的证据主要来自关联研究和观察队列,缺乏验证和随机试验数据来指导阿司匹林治疗.
- 血管原生生物标志物用于晚期怀孕诊断/预后,但是在第一季度风险分层和阿司匹林治疗修改方面进行研究.
结论:
- 生物标志物提供了对妊娠前和阿司匹林反应异质性的见解,但生物标志物引导的阿司匹林策略尚未在临床上得到验证.
- 目前的指导方针建议继续根据既定的风险评估进行阿司匹林预防,并保留生物标志物信息的方法用于未来的研究等待随机试验.
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