在印度 (I-INFUSE):多中心观察性研究中的选择性主要胃肠道癌症手术中,INtraoperative Fluid治疗的实践模式:多中心观察性研究
Sohan Lal Solanki1, Reshma Ambulkar2, Virinchi Sanapala2
1Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Indian journal of anaesthesia
|March 6, 2026
概括
在重大胃肠道癌症手术中,手术内流体治疗至关重要. 高流体率,失血和输血增加了并发症,而微创手术缩短了住院时间.
科学领域:
- 麻醉学和外科手术期间的医学.
- 手术瘤学手术瘤学
- 关键护理医学 关键护理医学
背景情况:
- 术内流体治疗对于优化主要腹部手术的结果至关重要.
- 由于类型,数量,速率和策略的不确定性,流体的临床实践有所不同.
- 手术前的流体缺陷和手术内流体损失进一步使这些患者的流体管理复杂化.
研究的目的:
- 评估主要胃肠癌手术中的手术内流体治疗实践.
- 确定与术后并发症和结果相关的因素.
- 将当前的做法与国际共识指南进行比较.
主要方法:
- 一项多中心观察性研究,涉及810名在印度接受重大胃肠道癌症手术的患者.
- 数据收集包括患者人口统计,手术/麻醉细节,液体管理,血液动力学监测,血液损失,输血和术后并发症 (Clavien-Dindo, CCI).
- 进行多变量回归分析以确定结果预测因素,显著性设置为P < 0.05.
主要成果:
- 平均手术内液体的使用量为5.34毫升/千克/小时 (总体量为2648.5毫升).
- 手术后并发症的发生率 (CD ≥3) 为7.9%.
- 较低的手术前血清白蛋白,较高的流体速率,较大的血液损失和手术内输血与增加的发病率和CCI得分有关. 最少侵入性手术与更短的住院时间相关.
结论:
- 印度癌症中心的手术内流体治疗实践符合国际准则.
- 液体给药率和相关因素显著影响术后发病率.
- 优化流体管理对于改善主要肠道癌症手术的结果至关重要.
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