对草药诱导的肝损伤风险因素的分析:来自中国的回顾性研究
Pengchong Wang1,2,3, Xinyan Liang1,2,4, Guangyu Cheng5
1Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Frontiers in pharmacology
|March 6, 2026
概括
老年,代谢功能障碍和免疫系统疾病增加了草药诱导肝损伤 (HILI) 的风险. 识别这些因素有助于早期发现和管理HILI.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药物监督 药物监督 药物监督
- 临床毒理学 临床毒理学
背景情况:
- 草药的使用很常见,但可能导致肝损伤.
- 草药诱导的肝损伤 (HILI) 提出了诊断上的挑战.
- 识别风险因素对于患者管理至关重要.
研究的目的:
- 在草药治疗后分析肝损伤患者的临床和实验室特征.
- 为了确定草药诱导肝损伤 (HILI) 的风险因素.
- 为HILI.开发一个预测模型.
主要方法:
- 对3914名肝功能异常和草药病史患者的回顾性研究.
- 176名患者使用RUCAM诊断出HILI.
- 使用后勤回归开发的预测模型与AUC和DCA进行了验证.
主要成果:
- 高龄,肝脏代谢功能障碍和免疫障碍是HILI的重要危险因素.
- 性酸酶 (ALP) 被确定为一个独立的风险因素.
- 预测模型在培训和验证集中显示出良好的表现 (AUC,DCA).
结论:
- 患有晚年,代谢功能障碍或免疫障碍的患者患HILI的风险更高.
- 开发的模型可以帮助预测HILI风险.
- 早期识别风险因素可以指导预防策略.
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