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慢性便秘的饮食策略:聪明地准激素和反射通路,以获得最佳的恢复

Emanuela Ribichini¹, Giulia Scalese¹, Chiara Mocci¹

¹Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Frontiers in pharmacology

|March 6, 2026

概括

慢性便秘 (CC) 管理需要更好的营养. 拟议的SMART便秘饮食 (SCD) 整合了多种饮食因素,以改善肠道运动性和缓解症状,提供了一种超出单个干预措施的新方法.

科学领域:

胃肠病学和营养科学胃肠病学和营养科学
肠-大脑相互作用障碍肠-大脑相互作用障碍
消化系统健康和运动能力

背景情况:

慢性便秘 (CC) 显著影响生活质量,目前治疗方法往往管理不善.
现有的治疗方法为许多患者提供了低于最佳的缓解,强调了需要新的,基于生理学的营养策略的需要.
影响肠道运动的营养途径包括肠内分泌信号,胆酸代谢,微生物代谢物和味觉受体激活.

研究的目的:

提出一个结构化,基于生理学的营养框架来管理慢性便秘.
将营养物质对肠道运动作用的多种机制整合到一个连贯的饮食模型中.
引入感觉,运动,胆汁酸和反射量身定制 (SMART) 便秘饮食 (SCD) 作为一种产生假设的概念.

主要方法:

审查现有证据对营养物质对肠道运动的影响.
确定关键途径:纤维类型,胆汁流,微生物调节和感官刺激.
制定框架,使饮食成分与运动现象型和发酵耐受性保持一致.

主要成果:

可溶性纤维 (psyllium),果,果和特定的矿泉水显示了改善便频率和一致性的一致证据.
其他干预措施,如发酵食品,益生菌和水合,具有可变的疗效,通常由生理学数据支持.
智能便秘饮食 (SCD) 框架整合了纤维,胆汁,微生物和时间营养策略.

结论:

智能便秘饮食 (SCD) 是一种用于慢性便秘的精密营养的翻译概念.
协调,多途径的饮食调节需要进一步研究.
未来需要随机对照试验来验证SCD并将其与单组件干预进行比较.

关键词:

慢性便秘慢性便秘时间-营养定时表肠内分泌信号传递系统胃结肠反射是一种反射.肠道大脑轴肠道大脑轴个性化的营养个性化的营养

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