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通过IGHV4-34抗体的外来和自我甘氨酸的框架中介结合

David B Langley1, Christopher J Jara1,2, Jake Y Henry1

  • 1Immune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Frontiers in immunology
|March 6, 2026
PubMed
概括

冷凝固蛋白疾病涉及自我反应性抗体攻击红细胞. 新的结构洞察力揭示了一个独特的抗体特征直接参与目标糖,解释了自身免疫反应.

关键词:
FR1 水性补丁在IGHV4-34抗体.寒冷的凝聚素自身抗体,即冷凝聚素自身抗体.感冒凝聚素疾病 感冒凝聚素疾病甘氨酸-抗体接口接口

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