性结肠炎中纳米基疗法的结构和时间动态:历史,热点和新兴趋势
Junzu Shi1, Danyang Cui1, Li Yu1
1Department of Traditional Chinese Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Frontiers in immunology
|March 6, 2026
概括
性结肠炎 (UC) 的纳米材料疗法正在增长,研究正在转向智能,机制引导的策略. 未来的工作应该专注于纳米设计,安全性和个性化治疗,以获得更好的结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 胃肠病学 胃肠病学
背景情况:
- 基于纳米材料的疗法为治疗性结肠炎 (UC) 提供了一个有前途的途径.
- 进行了全面的文献分析,绘制了UC纳米疗法研究格局.
- 该研究旨在了解知识的演变,确定核心主题,并揭示这一领域的新兴趋势.
研究的目的:
- 在过去的25年里,系统地分析和绘制纳米材料治疗性结肠炎 (UC) 的研究趋势.
- 确定UC纳米疗法中的关键研究主题,合作模式和新兴领域.
- 提供对该领域发展的见解,并指导未来的研究方向.
主要方法:
- 在2001-2025年间对1316个英语出版物的图书统计分析,来源于Web of Science和Scopus.
- 利用CiteSpace,HistCite和R软件来分析协作网络,关键字的共同出现,共同引用和主题演变.
- 关键词包括"纳米材料"和"性结肠炎";包括原创文章和评论.
主要成果:
- 在UC纳米疗法领域显示持续增长与越来越多的国际合作,由中国领导.
- 关键的新兴主题包括肠道微生物群调节,反应性氧物种向,NLRP3炎症酶抑制,先进的药物递送系统和聚合物纳米粒子.
- 研究正在从被动药物输送转向智能,机制驱动和组合疗法,其中核心领域是炎症调节和向输送.
结论:
- UC纳米疗法研究领域正在向精确,智能和机制引导的策略发展.
- 未来的研究应该优先考虑纳米设计,全面的安全评估和个性化纳米疗法的开发.
- 通过专注于这些关键领域,可以促进UC纳米疗法的翻译性创新.
更多相关视频
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
578
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
578
Inflammatory Bowel Disease I: Ulcerative Colitis
1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
Inflammatory Bowel Disease IV: Pharmacological Management
874
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
874
Peptic Ulcer Disease II: Pathophysiology
2.4K
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
2.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
987
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
987
Chronic Bowel Disorders: Introduction
867
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
867


