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相关概念视频

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
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一条通往免疫工程的多能道路

Yun Chang1,2, Qing Deng2,3, Xiaoping Bao1,2

  • 1Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, US.

Nature reviews bioengineering
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概括
此摘要是机器生成的。

化学抗原受体T细胞疗法对血液癌症有希望,但面临挑战. 人类多能干细胞为采用免疫疗法提供了一个可扩展,具有成本效益的替代方案.

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科学领域:

  • 免疫治疗是一种免疫疗法.
  • 血液瘤学 血液瘤学
  • 干细胞生物学 干细胞生物学

背景情况:

  • 采用免疫疗法,特别是嵌合抗原受体T细胞 (CAR-T),已经彻底改变了血液恶性瘤的治疗.
  • 目前的CAR-T疗法面临的局限性包括患者特异性的细胞工程,高成本和大量的时间承诺.
  • 这些挑战限制了CAR-T疗法的广泛应用.

研究的目的:

  • 探索人类多能干细胞 (hPSCs) 作为采用免疫治疗的潜在替代方案.
  • 通过利用hPSC来解决患者衍生的CAR-T细胞的局限性.
  • 研究一种现成的,可扩展的,具有成本效益的细胞疗法解决方案的可行性.

主要方法:

  • 利用人类多能干细胞作为细胞工程的来源.
  • 从hPSCs开发可扩展的治疗细胞生产方法.
  • 评估产生"现成"全源细胞产品的潜力.

主要成果:

  • 人类多能干细胞为自身细胞来源提供了一个可行的替代方案.
  • 从hPSC衍生的疗法可以克服与患者衍生的细胞相关的变异性.
  • 这种方法有可能降低制造成本并增加可扩展性.

结论:

  • 人类多能干细胞为开发下一代采用性免疫疗法提供了一个有希望的平台.
  • 基于hPSC的策略可能会使获得先进的癌症治疗方法的机会更为民主化.
  • 这项研究为更容易获得和负担得起的血液恶性瘤治疗铺平了道路.