CRABP1信号体在网酸的非法典作用中 - - 维持健康,防止老化中的甲状腺功能障碍
Jennifer Nhieu1, Fatimah Najjar1, Li-Na Wei1
1Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
概括
细胞视网膜酸结合蛋白1 (CRABP1) 形成信号体,调节细胞功能. 在CRABP1中,
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 视网膜酸 (RA) 信号由RA受体 (RARs) 和非正规通路介导.
- 细胞RA结合蛋白1 (CRABP1) 通过细胞质信号传递调解快速的,RAR独立的RA活动.
- CRABP1形成信号体,蛋白质复合体以特定细胞类型的方式调节信号传播.
研究的目的:
- 审查CRABP1信号体及其生理功能.
- 突出CRABP1在衰老和疾病中的作用,特别是甲状腺功能障碍.
- 探索针对CRABP1.1的治疗策略.
主要方法:
- 对CRABP1信号体及其功能现有文献的综述.
- 在CRABP1淘汰赛 (CKO) 小鼠中的表型分析.
- 在人类和小鼠中检查CRABP1基因调节和表达模式.
主要成果:
- CRABP1淘汰赛小鼠表现出渐进的表型,包括改变的大脑功能,肥胖,胰岛素抵抗,心力衰竭脆弱性和甲状腺功能障碍.
- 甲状腺的CRABP1表达随着年龄的增长而增加,这将其与与年龄相关的疾病联系起来.
- CRABP1序列的保存表明在信号体形成中的功能重要性.
结论:
- CRABP1信号体对维持健康和器官功能至关重要,特别是在衰老期间和甲状腺中.
- CRABP1失调与年龄是一个因素的人类疾病有关.
- 用特定化合物准CRABP1为甲状腺功能障碍等疾病提供了潜在的治疗策略,最大限度地降低了视网类毒性.
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