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相关概念视频

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...

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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
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评估小鼠中微剂量迷幻LSD的潜在心血管风险.

Devin P Effinger1, Serena S Schalk1,2,3,4, Jillian L King1

  • 1Laboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.

ACS pharmacology & translational science
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概括

微剂量 lysergic acid diethylamide (LSD) 在小鼠中没有显示出不良的心血管影响,与已知的心脏毒素不同. 这项研究表明,低剂量的LSD可能不会引起心脏病,尽管有5-HT2B受体相互作用.

关键词:
5-HT2B受体的受体是什么这是一种LSD,一种LSD.心血管疾病的心血管疾病微量注射是一种微量注射.迷幻药物 迷幻药物是一种精神药物.

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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科学领域:

  • 心血管药理学心血管药理学
  • 神经科学是一个神经科学.
  • 药品安全 药品安全

背景情况:

  • 微剂量迷幻药对于感知到的好处很受欢迎.
  • 迷幻药与5-HT2B受体相互作用,与心脏病有关.
  • 长期激活5-HT2B受体可能导致心脏问题.

研究的目的:

  • 为了研究微剂量迷幻药物对心血管的影响.
  • 评估长期服用低剂量 lysergic acid diethylamide (LSD) 对小鼠心脏健康的影响.
  • 为了比较LSD的5-HT2B受体激活特征与已知的心脏毒素.

主要方法:

  • 小鼠接受了慢性服用血清素,d-fenfluramine,或LSD在低于幻觉的剂量.
  • 心声图被用来评估心血管健康.
  • 确定了LSD,psilocybin和norfenfluramine在5-HT2B受体上的结合亲和力和强度.

主要成果:

  • 血清激素诱导了显著的腹腔厚化;d-fenfluramine引起了大动脉的反.
  • 在用LSD或车载治疗的小鼠中没有观察到显著的心血管变化.
  • 与d-fenfluramine相比,LSD的5-HT2B受体激活是相当大的,但寿命短暂的.

结论:

  • 在小鼠中长期服用低剂量的LSD没有显示出心脏重塑的证据.
  • 由LSD激活5-HT2B受体的短暂性质可能会减轻心脏毒性风险.
  • 这些发现不支持在这个模型中LSD微剂量引起心脏病的担忧.