心肌病中的冠状动脉微血管功能障碍:对临床和预后作用的见解
Federico Giacobbe1,2,3, Pierre Meynet1,2, Marco Balducci1,2
1Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, 10126 Turin, Italy.
Reviews in cardiovascular medicine
|March 6, 2026
概括
冠状动脉微血管功能障碍 (CMD) 显著影响心肌病的结果. 早期诊断和针对性治疗CMD对于改善患者预后和风险分层至关重要.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 翻译医学是一种翻译医学.
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 越来越被认为是各种非缺血性心肌病的病理生理学和预后的一个关键因素.
- 了解CMD在不同心肌病的作用对于改善患者管理和结果至关重要.
研究的目的:
- 审查微血管功能障碍的诊断工具.
- 总结关于CMD发病率及其在心肌病患者的预后意义的证据.
- 探索目前和潜在的CMD治疗策略.
主要方法:
- 对CMD的诊断方式的文献综述.
- 综合证据关于CMD患病率和预后影响在扩张,高,Takotsubo,心律失常的右心室和透性心肌病.
- 对针对CMD的治疗干预措施的分析.
主要成果:
- 冠状动脉疾病 (CMD) 是普遍存在的,并且与扩张性和多变性心肌病变的不良结果有关.
- 在Takotsubo综合征中,CMD是急性和可逆的,通常涉及.
- 初步数据表明,CMD参与了心律失常的右心室心肌病变,而它是透性疾病的早期特征,如粉样菌症和安德森-法布里病,并且与粉样菌症的炎症有关.
结论:
- 将微循环评估纳入临床实践可以提高心肌病患者的风险分层.
- 虽然目前的向疗法有限,但CMD是一个重要的治疗目标.
- 对基于设备和非药物策略的进一步研究是有必要的,以有效地解决跨心肌病的CMD.
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