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固体水凝连接器用于皮肤表面血流成像与超分辨率超声波

Yunlong Bao¹, Hao Yu¹, Yu Xia¹

¹School of Mechanics and Engineering Science, Peking University, Beijing, People's Republic of China.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

|March 6, 2026

概括

一种新的固体水凝合介质 (SA-PAM) 通过减少探针压力器件和近场干扰来改善皮肤表面的血流超声成像. 这增强了潜在的临床应用的微血管可视化.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
材料科学材料科学材料科学

背景情况:

超声波传感器压力损害了表面血流成像的准确性.
近场声学干扰进一步降低了图像质量.
皮肤微血管结构的高分辨率成像仍然是一个挑战.

研究的目的:

引入一种新的固体水凝合介质,用于增强表面血流超声波成像.
克服探头压力和声学干扰的限制.
提高皮肤微血管可视化的精度和分辨率.

主要方法:

制造了一个甲基酸盐和烯胺 (SA-PAM) 固体水凝合.
通过拉力测试进行了机械表征.
使用超声波局部化显微镜 (ULM) 在老鼠皮肤上以微气泡对比剂的不同压力评估成像性能.

主要成果:

该SA-PAM水凝显示出优异的声学合和降低近场干扰.
与液体剂相比,皮肤和皮下微血管结构的可视化显著增强,即使在压力下.
3D超分辨率超声波成像显示了微血管流动连续性和血管密度的改善.

结论:

SA-PAM水凝合为皮肤表面血流的高分辨率超声波成像提供了一种新的解决方案.
减少由探针压力引起的图像扭曲,提供更好的血管成像.
显示了早期发现糖尿病中微血管病变和监测炎症性皮肤疾病的潜力.

关键词:

皮肤的微循环.固体水凝合片合片超声波学超声波学超声波学

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