[撤回]NRC‐AN‐019的设计,合成和临床前评估
Kompella Amala1, A K S Bhujanga Rao1, Bharathi Gorantla2
1Natco Research Centre, Sanath Nagar, Hyderabad 500-018, India.
International journal of oncology
|March 6, 2026
概括
这项对实验小鼠的研究因在光酶成像实验中重复图像而被撤回. 由于担心数据重复和作者缺乏回应,该期刊对所提交的数据失去了信心.
科学领域:
- 在瘤学瘤学.
- 生物医学研究生物医学研究
- 科学出版伦理学 出版伦理学
背景情况:
- 之前在国际瘤学杂志上发表的一篇论文面临着对其实验数据的审查.
- 一位读者表示担心,图像重复显示实验小鼠.
研究的目的:
- 为了解决有关发表的研究中潜在的数据重复和图像操纵的担忧.
- 保持科学完整性和读者对发表的研究的信心.
主要方法:
- 图像的审查 (图. 4A和5A) 来自实验研究.
- 评估鼠标定位和光酶成像细节的数据一致性.
主要成果:
- 在不同的数据集中识别出几组异常相似的小鼠.
- 在纸张中检测显著的数据重复.
结论:
- 该论文因对所提供的数据缺乏信心而从"国际瘤学杂志"上撤回.
- 在确定数据重复和作者未能回复编辑询问后,撤回发布.
更多相关视频
相关概念视频
01:28Preclinical Development: Overview
6.2K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.2K
01:29Clinically Relevant Drug Product Specifications: Methods of Establishment
275
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
275