功能成像在细胞癌中的新兴作用:从形态学到PET/计算机断层扫描的分子表型化
Geetha Guduguntla1, Sidney M Levy, Michael S Hofman
1Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia.
Current opinion in oncology
|March 6, 2026
概括
新型PET/CT追踪剂针对碳酸酶IX (CA-IX) 显示出改善清细胞细胞癌 (ccRCC) 检测和特征的前景. 这些进步促进了ccRCC管理中的个性化治疗和治疗术.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是指放射学
- 核医学是一种核医学.
背景情况:
- 细胞癌 (RCC) 的功能成像已经显著进步,新的放射性追踪剂正在出现用于诊断,分期和预后.
- 清洁细胞RCC (ccRCC) 是主要关注的焦点,临床依赖于先进的成像技术越来越多.
研究的目的:
- 在ccRCC中审查最近关于PET/CT成像的出版物.
- 突出功能成像在ccRCC的特征化中的不断变化的作用.
主要方法:
- 在ccRCC中对PET/CT成像的最新出版物的审查.
- 评估各种辐射追踪器,包括18F-FDG,68Ga-PSMA和CA-IX向的追踪器.
主要成果:
- 18F-FDG PET/CT在RCC分期中具有有限的价值,这是由于脏分泌和可变的吸收.
- 68Ga-PSMA PET/CT显示出潜力,但缺乏特异性.
- 针对CA-IX的标志物提供高瘤与背景比率和优异的病变检测,区分ccRCC与其他病变,并检测转移.
- 新型的小分子和CA-IX标记器允许在同一天进行成像,质量提高,剂量降低.
- 与配对的治疗177Lu-模拟物相结合的治疗应用具有前景.
结论:
- 功能性成像正在从解剖评估转向RCC中的分子表征.
- 进步使患者能够更好地选择治疗,个性化治疗和新型治疗术.
- 需要前性试验来验证性能,并将这些工具整合到临床途径中.
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