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Updated: Mar 7, 2026

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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在阿尔茨海默氏病中,HDAC6调节BACE1稳定性和NLRP3炎症酶激活

Jeongmi Lee1, Yongeun Cho1, Bo Youn Choi1

  • 1School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Brain : a journal of neurology
|March 6, 2026
PubMed
概括

基斯脱乙酶6 (HDAC6) 通过增加粉样β (Aβ) 生产和神经炎症驱动阿尔茨海默病. 在小鼠模型中,抑制HDAC6降低了Aβ,炎症,并改善了认知能力.

关键词:
阿尔茨海默氏症 (AD) 是一种疾病.在BACE1中获得了BACE1学位.在 HDAC6 中.在NLRP3炎症酶体中,NLRP3炎症

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