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用于乳腺癌治疗的可注射的带有埃托波的德克斯纳米颗粒:物理化学表征,细胞毒性研究,巨细胞活性和基因表达造型研究

Sivakumar S Moni^1,2, Marwa M Qadri^2,3, Jobran M Moshi^2,4

¹Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Nanomedicine (London, England)

|March 6, 2026

概括

可注射的硫酸德克斯纳米颗粒 (ETP-DNPs) 在乳腺癌治疗方面表现有前途. 这些纳米颗粒有效地输送埃托,诱导癌细胞亡,并抑制迁移,验证了它们作为纳米载体系统的潜力.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

乳腺癌仍然是全球主要的死亡原因.
有效的药物输送系统对于改善治疗结果和减少副作用至关重要.
埃托胺是一种强效的化疗剂,在传统的输送中存在局限性.

研究的目的:

开发和描述可注射的硫酸德克斯纳米粒子 (ETP-DNPs).
评估ETP-DNP用于乳腺癌治疗的体外性能.

主要方法:

使用离子凝合成ETP-DNP.
描述包括尺寸,形态 (SEM),稳定性 (泽塔潜力) 和热分析 (DSC,TGA).
在体外研究中评估了药物释放,细胞毒性 (MCF-7细胞),巨细胞激活 (IL-6) 和与亡相关的基因表达 (qRT-PCR).

主要成果:

ETP-DNP显示出最佳的大小 (9.5 nm),稳定性 (-33.2 mV) 和高药物负载 (83.3%) 和封装 (84.6%).
在体外,ETP-DNP表现出持续的药物释放,对MCF-7细胞的剂量依赖性细胞毒性,并通过内在途径诱导细胞亡.
治疗抑制了MCF-7细胞迁移,并证实了M1巨细胞的激活.

结论:

ETP-DNP是一种稳定且有效的纳米载体,用于以托化物输送.
开发的纳米粒子显示了乳腺癌治疗的巨大潜力.
对ETP-DNP的进一步研究可能会导致改进的癌症疗法.

关键词:

在BCL2中,BCL2是这就是巴克斯巴克斯巴克斯巴克斯.乳腺癌乳腺癌乳腺癌细胞亡细胞亡带有乙氧化物载荷的硫酸纳米颗粒 (ETP-DNP)在 p53 里,p53 是一个 p53 的类型.细胞毒性细胞毒性离子型凝技术离子型凝技术

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