在急性胰腺炎患者的肠道病毒和代谢关联
Min Liu1, Lvyue Wang1, Jianjun Liu2
1Department of Critical Care Medicine, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
mSystems
|March 6, 2026
概括
在急性胰腺炎 (AP) 中,肠道病毒组发生了显著的改变,显示出减少的多样性和独特的病毒群落. 这些变化与疾病严重程度相关,可以帮助分类AP,提供新的诊断和治疗途径.
科学领域:
- 微生物学和病毒学
- 胃肠病学 胃肠病学
- 系统生物学 系统生物学
背景情况:
- 急性胰腺炎 (AP) 是一种具有严重后果的重大炎症状况.
- 肠道屏障功能障碍在AP中至关重要,但病毒组的作用还未得到充分研究.
- 已知细菌失生症,但AP中的病毒社区转移需要全面的分析.
研究的目的:
- 在急性胰腺炎 (AP) 患者中全面描述肠道病毒组变化.
- 评估病毒组变化,AP严重程度,病因和临床参数之间的关联.
- 探索肠道病毒体签名在AP中的诊断潜力.
主要方法:
- 来自AP患者和健康对照 (HC) 的肠道病毒组的元基因组测序.
- 病毒多样性,分类学,功能和预测的病毒与宿主相互作用的生物信息分析.
- 构建微生物-病毒-代谢物网络和用于分类的机器学习.
主要成果:
- 与HC相比,AP病毒显著减少了病毒多样性和独特的社区组成.
- 与AP相关的菌体向特定的细菌,而与HC相关的菌体与共生动物联系在一起;病毒功能基因不同.
- 一个由七个病毒组成的小组在分类AP时取得了97.5%的准确性,与疾病严重程度和代谢标记相关联.
结论:
- 急性胰腺炎的特征是与疾病严重程度和病因学相关的深度肠道病毒组重塑.
- 肠道病毒组的改变代表了AP诊断和分层的潜在生物标志物.
- 了解病毒在AP中的作用为病原和治疗策略提供了新的见解.
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