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东亚冠状动脉病患者的CRP截止值:系统性审查和元分析

Yu-Yan Xiong¹, Miao Yu¹, Qi Long¹

¹Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education, Wuhan, Hubei, China.

|March 6, 2026

概括

东亚冠心病 (CHD) 患者的C反应性蛋白 (CRP) 水平低于西方人群. 1.0 mg/L或更高的CRP水平有效预测这些患者的预后不佳.

科学领域:

心脏病学心脏病学
炎症生物标志物炎症生物标志物
流行病学流行病学

背景情况:

C-反应蛋白 (CRP) 是西方冠心病 (CHD) 患者的已知预后标志物.
东亚人口表现出较低的基线CRP水平,需要进行具体的评估.
了解CRP在东亚CHD中的作用对于风险分层至关重要.

研究的目的:

为了确定东亚CHD患者中CRP的炎症风险切断值.
在这个人群中分析CRP水平与主要不良心血管事件 (MACE) 之间的关联.

主要方法:

来自PubMed,Embase,Cochrane图书馆和Scopus的研究的系统审查和元分析.
包括报告CRP水平和MACE发病率 (因任何原因死亡,心肌梗塞,中风,再血管) 的研究.
分析了8项涉及21,455名患者的研究数据.

主要成果:

增加的CRP水平与增加的MACE风险显著相关 (RR: 1.41,95% CI: 1.22-1.63).
东亚CHD患者的中位数CRP水平为1.2 mg/L,低于西方队列.
一个CRP值≥1.0 mg/L,不≥2.0 mg/L,更好地预测了不良预后.

结论:

东亚CHD患者中CRP水平的中位数为1.2 mg/L.
血清CRP水平≥1.0 mg/L是炎症风险的适当指标.
血血压≥1.0 mg/L是东亚心脏病患者预后不佳的适当预测指标.

关键词:

在C-反应性蛋白质中.冠心病是一种冠心病.主要的心血管不良事件.预后预后预后

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