相关实验视频
Updated: Mar 7, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
从20岁到85岁的中国人口范围内的脂质轨迹:性别和肥胖特异性模式
Yanyan Zhang1, Yijin Pei1, Yanzhi Yan1
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, China.
这项研究揭示了性别特定的脂质轨迹,在整个寿命中受到肥胖的影响. 建议对脂质管理和肥胖进行早期,根据性别和年龄量身定制的干预措施.
科学领域:
- 心血管健康 心血管健康
- 代谢健康 代谢健康
- 纵向队列研究 纵向队列研究
背景情况:
- 对脂质轨迹中的自然生命周期模式的理解有限.
- 肥胖对脂质的性别特异调节的表征不佳.
研究的目的:
- 为了描述整个成年期的性别特异性脂质轨迹.
- 检查肥胖指标对这些轨迹的影响.
主要方法:
- 分析了83,487名中国成年人的纵向队列,并进行了2-4次重复的脂质测量.
- 应用通用添加混合模型来定义与年龄相关的脂质轨迹.
- 通过体重指数和腰围来评估修改.
主要成果:
- 总胆固醇,LDL-C和非HDL-C显示三相轨迹;甘油三和残留胆固醇显示两相轨迹.
- 女性表现出延迟的轨迹过渡和更不利的晚成年期脂质谱.
- 肥胖指标与脂质升高有关,男性的相关性更强;减肥的降脂效应因性别和年龄而异.
结论:
- 肥胖对终身脂质轨迹产生性别特异性的影响.
- 研究结果表明,对于早期的脂质管理和肥胖干预,需要针对性别和年龄的具体策略.
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