和结构性大脑异常在脊柱裂开口的发病率
L R Koomen1, M Dremmen2, C Kik1
1Department of Neurosurgery, Erasmus MC University Medical Centre Rotterdam, P.O. Box 2060, 3000 CB, Rotterdam, the Netherlands.
概括
脊柱裂开口 (SBA) 患者经常出现大脑异常,但不如预期. 网络分析揭示了SBA中常见的同时发生的大脑异常.
科学领域:
- 神经学 神经学
- 发展生物学 发展生物学
- 医疗成像医学成像
背景情况:
- 脊柱裂开口 (SBA) 与各种大脑异常有关,可能影响发育.
- 在SBA患者中,结构性大脑异常和之间的关系需要进一步调查.
研究的目的:
- 为了确定SBA患者脑异常和的患病率.
- 在SBA中探索大脑结构异常和之间的关联.
主要方法:
- 在产后治疗SBA患者 (2000-2018年) 的回顾性横截面队列研究.
- 通过MRI评估结构性大脑异常,通过医疗记录评估.
- 利用网络分析来识别同时发生的异常.
主要成果:
- 包括91名SBA患者;7.0%患有.
- 常见的MRI发现包括2型奇亚里形 (89.2%) 和心室隆起 (94.7%).
- 网络分析发现了一组同时发生的异常:CMII,心室巨,体失生以及大质量介质.
结论:
- 这项研究描述了SBA患者大脑异常的频谱和并发模式.
- 在SBA患者中发病的发病率为7.0%,低于之前报告的水平.
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