在澳大利亚人口中,可修改的风险因素与视网膜年龄差距增加有关
Yuqing Lu1,2, Ruiye Chen1,2, Samantha Sze-Yee Lee3,4
1Centre for Eye Research Australia; Ophthalmology, University of Melbourne, Melbourne, Australia.
GeroScience
|March 6, 2026
概括
视网膜年龄差距 (RAG) 是衡量生物衰老的一种指标,与较高的静缩血压,静缩血压,BMI,酒精消耗和HbA1c相关. 识别这些风险因素可以有助于促进健康老龄化和减少疾病负担.
科学领域:
- 眼科医生 眼科 眼科
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 视网膜年龄差距 (RAG) 通过将视网膜预测年龄与时间学年龄进行比较来量化生物衰老.
- RAG与增加的死亡率和慢性疾病风险有关.
- 识别较高RAG的风险因素对于理解和促进健康衰老至关重要.
研究的目的:
- 确定与澳大利亚人口中较高RAG相关的社会人口统计学,生活方式和临床风险因素.
- 通过RAG.测量各种健康指标和生物衰老之间的关系.
主要方法:
- 在西澳大利亚的布塞尔顿健康衰老研究 (BHAS) 中,对4798名参与者的横截面研究.
- 视网膜年龄估计使用验证的深度学习模型应用于 fundus 照片.
- 使用多变量线性回归和限制立方分线 (RCS) 分析来检查风险因素和RAG之间的关联.
主要成果:
- 缩血压 (SBP),腹缩血压 (DBP),体重指数 (BMI),酒精消耗和糖化血红蛋白 (HbA1c) 与RAG显著和积极相关.
- 较高的SBP,DBP,BMI,酒精摄入量和HbA1c水平与视网膜年龄差距的增加相关.
- 这些发现突出了促进加速生物衰老的特定可修改的风险因素.
结论:
- 视网膜年龄差距 (RAG) 受几种临床和生活方式因素的影响,包括血压,BMI,酒精消耗和HbA1c.
- RAG对于流行病学研究,风险分层和促进健康衰老具有潜在的临床实用性.
- 这些发现支持使用RAG作为生物衰老和与年龄有关的疾病风险的生物标志物.
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