在神经外科手术后,D-二聚合物水平升高与深静脉血栓形成之间的关联
Maria Teresa Sartori1, Alessia Bozzolin2,3, Pietro Ciccarino4
1Clinical Medicine 1, Department of Medicine, University Hospital of Padua, Padua, Italy. mtsart@unipd.it.
Journal of thrombosis and thrombolysis
|March 6, 2026
概括
升高的D-二聚物水平可以帮助在神经外科手术后的患者中诊断深静脉血栓 (DVT). 1334μg/L的D-二聚合物值显示出对疑似DVT的高度敏感性,有助于早期检测.
科学领域:
- 神经外科 神经外科
- 血管医学 血管医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 神经外科患者面临高的术后血栓栓塞的风险,尽管预防.
- 在这个人群中,深静脉血栓症 (DVT) 的早期诊断具有挑战性.
研究的目的:
- 为了确定D-二次体水平的升高是否可以帮助诊断神经外科患者手术后的DVT.
- 研究神经外科手术后D-二聚物水平与DVT风险之间的关联.
主要方法:
- 556名神经外科患者的回顾性观察研究.
- 静脉超声波 (US) 对疑似DVT的评估,原因是D-二次体水平升高.
- 后勤回归和ROC曲线分析以确定D-二次元切线并评估DVT风险.
主要成果:
- 在73名患有D-二次体升高的患者中,有35人患有静脉血栓症,其中包括20名DVTs.
- 在患有DVT的患者中,D-二聚物水平显著更高 (或每1000μg/L增加1.98).
- 确定了1334μg/L (灵敏度0.90) 的最佳D-二次元切断值和2200μg/L (PPV 77%) 的值.
结论:
- 升高的D-二聚物水平与神经外科手术后DVT的风险增加有关.
- 特别是具有特定值的D-二聚体测试,可以帮助在神经外科患者中诊断术后的DVT.
- 需要进一步研究D-二聚体在血栓预防治疗中的作用.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
405
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
405
Venous Thrombosis III: Interprofessional Care
431
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
431
Venous Thrombosis I: Introduction
599
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
599
Venous Thrombosis IV: Nursing Management
333
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
333
Pulmonary Embolism III: Nursing Management
569
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
569
Peripheral Artery Disease V: Postoperative Nursing Management
486
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
486


