相关实验视频
Updated: Mar 7, 2026

08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
4.5K
在被动和强迫性高温症之后的肠上皮层差异性损伤
Sharifah Badriyah Alhadad1,2,3, Louisa Si Xian Lim1,2, Jason Kai Wei Lee1,2,3
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Block MD9, 2 Medical Drive Level 4, Singapore, 117593, Singapore.
Sports medicine - open
|March 6, 2026
概括
强迫性高温症,而不是被动性,在运动员中引起肠道损伤. 这表明热,新陈代谢和机械压力的结合,而不仅仅是高体温,导致胃肠道损伤.
科学领域:
- 运动生理学 运动生理学
- 胃肠道生理 胃肠道生理
- 环境生理学环境生理学
背景情况:
- 被动和运动性高温症可以损害胃肠道 (GI) 完整性,导致系统性问题和热中风.
- 肠上皮损伤是一个关键的早期事件,受热,代谢和机械压力因素的影响.
- 这项研究区分了被动 (PaH) 与运动性高温症 (RUN) 对肠道损伤的影响.
研究的目的:
- 为了比较被动高温症 (PaH) 和运动性高温症 (RUN) 对肠上皮损伤和内毒素转移的影响.
- 确定热,代谢和机械压力对肠道损伤的相对贡献.
- 探索长时间低强度运动 (WALK) 对肠道完整性的影响.
主要方法:
- 15名男性耐力运动员接受了随机的,平衡的条件:PaH (热水浸泡),WALK (长时间行走) 和RUN (跑步机运行).
- 所有条件都旨在达到39.5°C的核心体温 (Tc) 峰值,自愿疲劳,或60分钟.
- 测量包括Tc,心率,感知反应,以及肠脂肪酸结合蛋白 (IFABP) 和脂多糖 (LPS) 的度.
主要成果:
- 在PaH和RUN之间,峰值Tc类似,但在WALK中较低. 累积热负荷在WALK和RUN之间是相似的,但PaH较低.
- 在RUN和WALK之后,肠脂肪酸结合蛋白 (IFABP) 显著增加,但不是PaH.
- 与PaH和WALK相比,后条件IFABP在RUN中较高. 在所有条件下,LPS下降.
结论:
- 强迫性高温症,不是被动的,在匹配的核心高温下诱导肠道上皮损伤.
- 热,代谢和机械压力的结合,而不是单独升高的Tc,驱动GI损伤.
- 长时间的运动可能会导致亚临床肠道损伤,需要在热应变的同时管理运动负荷.
相关概念视频
Homeostatic Imbalances in Body Temperature
4.3K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.3K
Increased Body Temperature
7.6K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
Responses to Heat and Cold Stress
15.5K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
15.5K
Diversity of Archaea IV
563
Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
563
Factors Affecting Body Temperature
9.8K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
9.8K

