系统性硬化症相关死亡率的全球趋势,2001-2023年:使用世界卫生组织死亡率数据的流行病学分析
Keith Pardillada Belangoy1, Yoshito Nishimura2, Ko Harada3
1Department of Health Data Science, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, 7008558, Japan.
Clinical rheumatology
|March 6, 2026
概括
全球系统性硬化症 (SSc) 死亡率显示年龄标准化率下降,但原始率上升,女性受影响不成比例. 针对性战略对于高风险人群和地区至关重要.
科学领域:
- 流行病学 流行病学
- 自免疫性疾病 自免疫性疾病
- 公共卫生 公共卫生
背景情况:
- 系统性硬化症 (SSc) 是一种严重的自身免疫性疾病,具有显著的死亡风险.
- 了解全球死亡率趋势对于公共卫生倡议至关重要.
研究的目的:
- 分析系统性硬化症 (SSc) 相关死亡率的全球趋势.
- 为了检查年龄,性别和地理区域的差异.
主要方法:
- 利用了世界卫生组织的死亡数据库 (2001-2023年).
- 分析了原始死亡率 (SSc-CRs) 和年龄标准化死亡率 (SSc-ASMR).
- 当地加权的就业人数和Joinpoint回归用于趋势分析.
主要成果:
- 在74个国家报告了85,291例SSc死亡; 79.41%为女性.
- 在全球范围内,SSc-CR增加,而SSc-ASMR下降.
- 西太平洋的死亡率最高;美洲和欧洲的死亡率下降;中等SDI国家的SSc-ASMR最高.
结论:
- 全球年龄标准化SSc死亡率正在下降,但原始率正在上升,女性占主导地位持续.
- 在各地区和社会人口统计因素之间,SSc死亡率的差异仍然存在.
- 强调需要继续进行研究,提高疾病意识,并针对高风险群体进行有针对性的干预.
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