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双S和神经健康:神经毒性和潜在机制的综合概述

Xing Zhang^1,2, Linlin Wu³, Dingqi Hua¹

¹Department of Health Toxicology, College of Naval Medicine, Naval Medical University, No.800 Xiangyin Road, Shanghai, 200433, China.

Molecular neurobiology

|March 6, 2026

概括

双S (BPS) 暴露与神经毒性有关,影响大脑功能并增加多动症,阿尔茨海默氏症和抑郁症的风险. 需要进一步的研究来了解其机制和对神经健康的影响.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

双S (BPS) 是一种广泛存在的污染物,存在于各种人体组织中.
虽然被认为是一种内分泌干扰剂,但BPS越来越多地与神经毒性有关.
BPS的神经毒性特征和机制需要进一步阐明.

研究的目的:

系统地审查和综合关于Bisphenol S (BPS) 神经毒性特征和机制的证据.
通过流行病学,动物和细胞研究来界定BPS暴露与神经结果之间的关联.
为了解BPS神经毒性提出一个整合性框架.

主要方法:

2000年至2026年2月期间发表的流行病学,动物和细胞研究的系统检索和合成.
分析了来自14项流行病学和76项实验研究的数据.
整合发现,以确定神经毒性途径和修饰因素.

主要成果:

来自人类和实验研究的一致证据表明,与BPS暴露相关的神经毒性风险.
流行病学数据将BPS与ADHD,阿尔茨海默病和抑郁症的风险增加联系起来,与性别特定的模式.
动物和细胞研究揭示了包括内分泌干扰,氧化应激,神经递质失衡和肠-大脑轴扰动在内的机制.

结论:

暴露于BPS具有显著的神经毒性风险,影响行为,认知,并增加对神经精神疾病的易感性.
BPS神经毒性的机制是多因素的,涉及内分泌干扰,氧化应激和肠-大脑轴变化.
结合人类队列和机械学研究的进一步研究对于理解BPS在神经疾病中的作用和告知监管行动至关重要.

关键词:

行为障碍行为障碍双 S 是一种双醇.神经精神病学的结果.神经毒性神经毒性神经递质失衡是神经递质的失衡.

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