诺和恐慌发作风险:一个系统的审查和不成比例的分析,使用来自FDA不良事件报告系统 (FAERS) 数据库的个案安全报告
Keeirah Hiertika Raguram1, Manroop Sidhu1, Mohammad Ali Omrani1
1Department of Physiology and Pharmacology, Western University, London, Ontario, Canada.
The Journal of antimicrobial chemotherapy
|March 6, 2026
概括
诺基诺抗生素与其他抗生素相比,与更高的恐慌发作风险有关. 需要进一步的研究来证实这种关联,并了解这些药物的中枢神经系统安全性.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 中枢神经系统 (CNS) 不良事件
背景情况:
- 诺基诺与中枢神经系统 (CNS) 的不良事件有关,包括焦虑和抑郁.
- 最近的病例报告表明,诺基诺使用与恐慌发作之间存在潜在的联系.
- 有限的证据需要进一步调查诺使用与恐慌发作之间的关联.
研究的目的:
- 系统地审查有关诺基诺使用和恐慌发作风险的现有文献.
- 用FDA不良事件报告系统 (FAERS) 数据库分析诺基诺使用和恐慌发作之间的关联.
- 为了比较与诺基诺相关的恐慌发作风险与其他抗生素类别的风险.
主要方法:
- 对MEDLINE和Embase数据库的系统文献审查.
- 使用FAERS数据 (2004Q1-2024Q4) 对西普洛素,莱沃素和莫西素进行的活性-比较器不成比例分析.
- 报告几率比率 (ROR),调整后的ROR和贝叶斯分析进行,以检测"恐慌发作"的安全信号.
主要成果:
- 系统性审查确定了12项研究,临床试验中的恐慌发作患病率从0.46%到1.76%不等.
- 不成比例性分析显示,与阿齐思罗米相比,化诺的恐慌发作风险增加了6倍.
- 与trimethoprim/sulfamethoxazole相比,诺基诺的恐慌发作风险增加了12倍,在所有分析中一致.
结论:
- 研究结果表明,诺基诺使用与恐慌发作风险增加之间存在关联.
- 需要进一步的药理流行病学研究来验证这些发现并确定因果关系.
- 结果提供了关于诺基诺中枢神经系统安全性概况的见解,突出了需要谨慎临床使用的必要性.
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