一种瘤寄存细菌通过lysopc介导的c-Jun/c-Fos激活促进子宫癌的进展
Chao Li1, Han Zhao2, Jingjing Wang3
1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China; Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 201204, China.
Cell reports
|March 6, 2026
概括
宫癌患者的肠道细菌多样性增加. 一种特定的细菌,Gordonia polyisoprenivorans GP-2,产生 lysophosphatidylcholine (lysoPC),通过激活关键癌症基因,促进瘤生长和转移.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 代谢学 代谢学 代谢学
背景情况:
- 瘤居住微生物群在宫癌的发展和进展中发挥着作用.
- 微生物群参与子宫癌的确切机制尚未完全理解.
研究的目的:
- 调查瘤寄存微生物群与子宫癌之间的联系.
- 阐明特定细菌影响子宫癌生长和转移的机制.
主要方法:
- 对宫癌患者与对照患者的微生物群多样性的比较分析.
- 在体内研究中,使用小鼠模型与Gordonia polyisoprenivorans GP-2的使用进行了实验.
- 代谢分析以确定细菌代谢物及其途径.
- 使用患者衍生子宫瘤器官的体外研究来评估基因激活.
主要成果:
- 宫癌患者的微生物群多样性增加,发现了8种特定的细菌物种.
- 在小鼠中,使用Gordonia polyisoprenivorans GP-2加速了宫癌的生长和转移.
- 发现GP-2可以将宿主胆代谢成溶酸胆 (lysoPC).
- 已经证明,溶解脂胆 (lysophosphatidylcholine,lysoPC) 可以激活患者衍生瘤器官中的瘤转录因子c-Jun/c-Fos.
结论:
- 戈尔多尼亚多利索普雷尼沃兰斯GP-2通过产生溶酸胆 (lysophosphatidylcholine) (lysoPC) 来促进子宫癌的进展.
- Lysophosphatidylcholine (lysoPC) 激活关键的瘤基因,突出显示了宫癌中一种新的微生物群与宿主相互作用.
- 针对像GP-2这样的瘤寄存细菌,为宫癌提供了一个潜在的治疗策略.
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