克罗恩病患者全身免疫炎症指数的临床价值
Jing Yan1, Rongkun Wang2, Xiaojing Zhang3
1Department of Gastroenterology, Peking University People's Hospital Qingdao Hospital, Women and Children's Hospital, Qingdao University, Qingdao, Shandong, China.
Medicine
|March 6, 2026
概括
系统性免疫炎症指数 (SII) 在克罗恩病 (CD) 患者中升高,与疾病活性相关. 作为诊断和评估CD严重程度的生物标志物,SII显示出前景.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 系统性免疫炎症指数 (SII),血小板与淋巴细胞比率 (PLR) 和中性粒细胞与淋巴细胞比率 (NLR) 是反映系统性炎症的新兴生物标志物.
- 在克罗恩病 (CD) 中SII的临床实用性尚未得到广泛研究.
研究的目的:
- 调查SII,PLR和NLR与CD之间的关联.
- 为了比较SII,PLR和NLR在评估CD疾病活性方面的潜力.
主要方法:
- 对119名CD患者和121名健康对照进行了回顾性研究.
- 使用CD活动指数,CD内镜严重性指数和CD简单内镜评分来评估疾病活动.
- 包括相关性和多重线性回归在内的统计分析.
主要成果:
- 与健康个体相比,CD患者的SII水平显著更高 (P < .05).
- SII,PLR和NLR与CD疾病活动指数正相关,表现优于CRP.
- 与PLR,NLR和CRP (AUC = 0.710) 相比,SII显示出与透性疾病的独立关联以及透性CD的优异诊断性能.
结论:
- SII是CD中的一个有价值的生物标志物,在患者中升高,与疾病活性相关.
- 与其他炎症标志物相比,SII在评估CD严重程度和诊断透性疾病方面表现出更好的潜力.
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.4K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.4K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
990
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
990
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
672
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
672
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
618
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
618
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.3K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.3K
01:29Inflammatory Bowel Disease IV: Pharmacological Management
875
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
875