相对脂肪量与类风湿性关节炎之间的关联:一个横截面研究
Yuanting Sun1, Ruiji Wu2, Yanze Lin3
1Fuyang TCM Hospital of Orthopedics Affiliated to Zhejiang Chinese Medical University (Hangzhou Fuyang Hospital of Orthopedics of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.
Medicine
|March 6, 2026
概括
较高的相对脂肪质量 (RFM) 与风湿性关节炎 (RA) 风险增加有关. 虽然RFM在评估与肥胖相关的RA风险方面比体重指数 (BMI) 有一些前景,但其临床应用目前有限.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 人类测量学 人类测量学.
背景情况:
- 肥胖是一种已知的类风湿性关节炎 (RA) 风险因素.
- 相对脂肪质量 (RFM) 是一个用于估计身体脂肪百分比的新型指数.
- 了解RFM与RA的关联可以为风险评估提供信息.
研究的目的:
- 调查RFM与发展RA的风险之间的关联.
- 为了比较RFM和身体质量指数 (BMI) 与RA风险相关的区分能力.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (1999-2018) 的横截面研究.
- 进行了加权多变量逻辑回归和子组分析.
- 使用了受限立方线 (RCS) 和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 在RFM和RA风险之间发现了显著的积极关联 (OR=1.048).
- 在最高的RFM四分位数中的个体具有显著更高的RA风险 (OR=2.487).
- 通过RFM,RA风险的区分比BMI (AUC=0.614对0.581) 略好一些.
结论:
- 增加的RFM独立地与较高的RA风险有关.
- 射频肌瘤和RA之间的关联是线性的,受年龄,教育和吸烟状况的影响.
- 虽然RFM显示出潜力,但其在预测RA风险方面的临床实用性需要进一步调查.
相关概念视频
Genome-wide Association Studies-GWAS
16.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.2K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
842
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
842
Rheumatic Heart Disease I: Introduction
699
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
699
Relative Risk
2.3K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.3K


