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糖尿病足中的有氧病原体概况和抗生素耐药性:来自约旦一家专门糖尿病中心的数据

Dana Hyassat¹, Mohammad Al Gazo¹, Faris Bakri^2,3

¹The National Center for Diabetes, Endocrinology, and Genetics, The University of Jordan, Amman, Jordan.

|March 6, 2026

概括

糖尿病足 (DFU) 常常受到格拉姆阳性细菌的感染,特别是金黄色葡萄球菌,具有很高的甲基西林耐药性. 有效的抗生素包括万科米辛用于克拉姆阳性和卡巴胺用于克拉姆阴性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
糖尿病学糖尿病学

背景情况:

糖尿病足 (DFU) 是糖尿病的一个严重并发症,经常导致严重的感染.
了解微生物景观和抗生素耐药性模式对于有效的DFU管理至关重要.

研究的目的:

确定感染和未感染的DFU中的有氧细菌概况和抗生素敏感性.
确定约旦DFU队列中占主导地位的病原体及其抵抗机制.

主要方法:

一项涉及171名DFU患者的国家糖尿病,内分泌学和遗传学中心 (NCDEG),约旦安曼的横截面研究.
采集表面拭子和组织样本用于有氧细菌培养和抗生素敏感性测试 (AST) 根据CLSI指南.

主要成果:

总共有260个分离物被确定,其中格拉姆阳性细菌 (GPB) 占65.1%,格拉姆阴性细菌 (GNB) 28.4%.
黄金葡萄球菌是最常见的GPB (39.8%),其中68.1%被确定为耐甲西林黄金葡萄球菌 (MRSA).
GPB对万科米辛,线索利德,tigecycline和teicoplanin表现出完全的敏感性;GNB对埃尔塔烯,梅罗烯,阿米卡辛和阿米烯最容易受到影响.

结论:

这个队列中的DFU主要是由GPB引起的,特别是S. aureus,MRSA的流行率很高.
抗生素敏感性数据强调了DFU中GPB和GNB感染的有效治疗选择.
对细菌流行病学和AST的持续监测对于指导DFU管理中的实证抗生素治疗至关重要.

关键词:

糖尿病糖尿病患者糖尿病患者糖尿病足部糖尿病足部多种药物耐药性多种药物耐药性

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