心理社会压力因素,加速的生物衰老和多重疾病:来自不同年龄段的样本证据
Gabriele Ciciurkaite1, Byungkyu Lee2, Siyun Peng3
1School of Social Sciences, Utah State University, Logan, Utah, United States of America.
PloS one
|March 6, 2026
概括
慢性压力,包括财务压力和歧视,加快生物衰老,影响心理健康比童年逆境更大. 了解多种压力因素是评估健康风险的关键.
科学领域:
- 心理社会流行病学心理学
- 生物衰老 生物衰老
- 在健康方面存在差异.
背景情况:
- 心理社会压力是健康状况不佳和死亡率的已知风险因素.
- 之前的研究经常检查单个压力因素,忽视累积寿命影响.
- 多种压力因素对健康和衰老的相互作用需要进一步研究.
研究的目的:
- 检查四种不同的心理社会压力和生物衰老之间的关联.
- 调查这些压力因素对身体和心理健康结果的影响.
- 确定哪些压力因素在同时考虑时最能预测加速衰老和不良健康.
主要方法:
- 利用来自2,267名成年人 (18-103岁) 的州代表样本的数据.
- 评估了四种心理社会压力因素:不良童年经历 (ACE),压力生活事件,慢性财务压力和日常歧视.
- 测量了基于DNA甲基化的生物衰老时钟 (GrimAge2,DunedinPACE) 和六个健康指标.
主要成果:
- 单独来看,这四种压力因素都与加速表观遗传衰老和健康状况恶化有关.
- 当分析在一起时,慢性财务压力和日常歧视是不利结果的更一致的预测因素.
- 与身体健康或生物衰老相比,对于心理健康结果,压力因素的影响更为明显.
结论:
- 多种心理社会压力因素对加速的生物衰老和负面的健康结果做出了重大贡献.
- 财务压力和歧视似乎是整个生命周期中特别强大的压力因素.
- 考虑累积压力暴露的综合方法对于了解健康风险和疾病至关重要.
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