相关实验视频
Updated: Mar 8, 2026

10:43
Dissection of Larval Zebrafish Gonadal Tissue
Published on: April 26, 2017
11.1K
在雌性分裂体中,男性激素升高的转录因子ZNF362.1决定了性成熟
Mengjie Gu1, Wenjun Cheng1, Shan Li1
1State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Science advances
|March 6, 2026
概括
男性激素通过ZNF362.1-CPEB1通路触发女性分裂体的成熟. 这一发现揭示了调节分裂体繁殖的关键分子机制,并为分裂体控制提供了新的标.
科学领域:
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
- 生殖生物学 生殖生物学
背景情况:
- 全球有超过2亿人患有istosomiasis.
- 雌性石虫卵子的生产驱动疾病传播和病理.
- 女性成熟的分子机制,由男性激素BATT调节,仍然不清楚.
研究的目的:
- 为了确定女性分裂体生殖发育的关键分子调节者.
- 为了阐明由男性激素BATT启动的信号通路.
- 为了发现潜在的目标,用于控制杆菌病.
主要方法:
- 对BATT-响应基因 *znf362* 的鉴定和功能分析.
- 单细胞转录组学和现场杂交以分析基因表达.
- 多基因组学分析以确定直接的基因标.
- 研究 *Sm*CPEB1 在卵细胞和白细胞分化中的作用.
主要成果:
- 转录因子基因 *znf362.1* 对于 BATT 诱导的卵巢和白菌成熟是必不可少的.
- 在BATT暴露时, *znf362.1* 在卵细胞和维泰拉里亚S1细胞中被上调.
- ZNF362.1 直接激活 *Smp_349410* (编码 *Sm*CPEB1),这是一个特定于女性生殖腺的基因.
- 失去了 *znf362.1* 或 *Smp_349410* 损害了卵细胞和白细胞的分化.
- *Sm*CPEB1调节环林B1mRNA的多化,并驱动S1细胞的分化.
结论:
- 一个BATT- *znf362.1* - *cpeb1*轴启动雌性分裂体的性成熟.
- 这一轴涉及转录和后转录调节.
- 了解这种途径,可以提供机理性的洞察力,了解体的繁殖和潜在的体病控制目标.
相关概念视频
Master Transcription Regulators
8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K
The Ratio of X Chromosome to Autosomes
10.0K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
10.0K
The Y Chromosome Determines Maleness
8.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
8.6K
Dosage Compensation
7.7K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
7.7K
Development of the Sexual Organs in the Embryo and Fetus
4.4K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
4.4K
Background and Environment Affect Phenotype
7.9K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.9K

