评估卢旺达B型肝炎和C型肝炎感染患者遵守肝细胞癌监测指南
Fidel Rubagumya1,2,3, Vincent Kwizera3, Phocus Havugimana2
1Rwanda Military Referral and Teaching Hospital, Kigali, Rwanda.
JCO global oncology
|March 6, 2026
概括
卢旺达的肝细胞癌 (HCC) 监测遵守率较低,许多B型肝炎病毒 (HBV) 和C型肝炎病毒 (HCV) 患者错过了推的查. 改善早期癌症检测需要更好地将HCC监测纳入肝炎护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 肝细胞癌 (HCC) 是撒哈拉以南非洲癌症死亡的主要原因.
- 慢性乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 感染是HCC的主要驱动因素.
- 卢旺达已经制定了使用腹部超声波 (US) 和α-fetoprotein (AFP) 测试进行半年HCC监测的国家指南.
研究的目的:
- 评估卢旺达的HBV和HCV感染患者遵守国家HCC监测指南.
- 确定国家转诊医院的HCC监测覆盖范围中的差距.
主要方法:
- 在2022年1月至2024年12月期间,对388名HBV/HCV患者进行了回顾性描述性研究.
- 根据US和AFP测试所覆盖的时间比例评估了监视遵守情况.
- 分类覆盖率为最佳 (100%),中等 (50%至99%) 或差 (<50%).
主要成果:
- 超过三分之一 (31.4%) 和近一半 (44.6%) 的患者从未分别接受过US或AFP测试.
- 只有15.5%的人获得了最佳的美国覆盖率和12.1%的最佳AFP覆盖率.
- 在年轻的成年人 (31-50岁) 和城市居民 (基加利) 中观察到低于最佳的坚持,而农村患者则表现出更好的坚持.
结论:
- 卢旺达对HCC监测指导方针的遵守程度不足于最佳水平,这表明存在重大差距.
- 有必要将HCC监测纳入常规肝炎护理中.
- 可以利用分散的卫生系统来加强卢旺达的早期癌症检测.
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