在微塑性压力下补充抗氧化剂:两动物的保护性或亲氧化作用
Jun-Kyu Park1, Ji-Eun Lee1, Jun-Sung Kim1
1Department of Biological Sciences, Kongju National University, 32588, Republic of Korea.
Journal of hazardous materials
|March 6, 2026
概括
食维生素C并没有完全保护Glandirana rugosa头免受微塑料 (MP) 压力,联合暴露加剧了氧化失衡. 这突出了复杂的抗氧化剂-污染物相互作用,并挑战了普遍的抗氧化剂保护假设.
科学领域:
- 环境毒理学环境毒理学
- 两动物生态毒理学
- 氧化应激研究研究 氧化应激研究
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,影响水生生物的健康.
- 对于MPs对两动物发育的影响以及抗氧化剂缓解的有效性尚不清楚.
- 氧化还原稳定性破坏是MP毒性的关键问题.
研究的目的:
- 为了研究饮食中维生素C对Glandirana rugosa的微塑料诱导压力的缓解作用.
- 评估慢性,环境相关的MP暴露对两动物发育,生理和抗氧化状态的影响.
- 探索微塑料和维生素C之间的潜在协同或对抗性相互作用.
主要方法:
- 长期暴露在环境相关的微塑料 (MP) 水平的Glandirana rugosa头.
- 饮食补充维生素C,单独或与MPs结合使用.
- 量化发育速度,生长,生存,皮质水平和抗氧化酶活性在各个本体遗传阶段的量化.
主要成果:
- 暴露于MP显著延迟了转化,降低了存活率,并破坏了氧化酶配置文件,表明持续的氧化还原破坏.
- 维生素C可以部分缓解发育迟缓,改善早期生长,但不能完全抵消MP引起的压力.
- 联合MP和维生素C的暴露导致了酶活性升高和亲氧化剂转移,这表明氧化应激加剧而不是保护.
结论:
- 食维生素C对微塑料压力的保护作用是有条件的,并且可以受到污染物相互作用的影响.
- 抗氧化剂可能与微塑料相互作用,可能会加剧两动物的氧化应激.
- 这些发现挑战了饮食中抗氧化剂的普遍保护假设,并强调需要现实的暴露评估.
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