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光周期干扰对硫酸 (PFHxS) 诱导的发育毒性产生影响

Syed Rubaiyat Ferdous¹, Alfredo Rojas², Cole Frank³

¹Department of Biological Sciences, Clemson University, Clemson, SC, USA; Environmental Toxicology Graduate Program, Clemson University, Clemson, SC, USA; Clemson University Institute of Human Genetics, Greenwood, SC, USA.

Journal of hazardous materials

|March 6, 2026

概括

环境照明显著影响了硫酸 (PFHxS) 的毒性. 暴露于PFHxS的斑马鱼胚胎表现出改变的行为和发育障碍,特别是在持续的黑暗中,突出了光周期在毒性评估中的重要性.

科学领域:

环境毒理学环境毒理学
时间生物学时间生物学
发育神经毒性发育神经毒性

背景情况:

perfluorohexane sulfonate (PFHxS) 是一种持久性环境污染物,具有潜在的发育神经毒性.
循环节律由光周期调节,影响生理过程,可以调节化学毒性.
由于人工照明和现代生活方式,自然光暗循环的破坏越来越普遍.

研究的目的:

为了研究光周期对斑马鱼胚胎中 perfluorohexane sulfonate (PFHxS) 毒性的影响.
为了确定环境照明条件是否会改变PFHxS吸收,内分泌干扰和发育结果.
评估光周期在PFHxS诱导的神经行为和眼睛效应中的作用.

主要方法:

斑马鱼胚胎在不同光周期下的度范围内暴露于PFHxS:14小时的光:10小时的黑暗 (14L:10D) 和持续的黑暗 (24D).
使用LC-MS测量PFHxS吸收,并通过光运动行为测定,黑激素水平分析和转录基因分析评估毒性.
基因表达分析的重点是DNA复制,细胞循环,氧化应激途径和眼睛特异性的发育标记.

主要成果:

在14L:10D和24D光周期之间,PFHxS的吸收是可比的.
与14L:10D周期相比,持续的黑暗 (24D) 加剧了PFHxS的毒性,导致过度活跃,高氧化应激,DNA损伤和抑制细胞增殖.
PFHxS在光周期之间不同地破坏了黑激素水平,并导致光周期特异的眼部发育异常,包括24D以下视网膜增殖细胞减少.

结论:

光周期是调节PFHxS暴露的毒理结果的关键因素.
持续的黑暗加剧了PFHxS诱导的发育神经毒性和斑马鱼胚胎中的内分泌干扰.
对PFHxS等持久化学品的风险评估必须考虑环境照明条件和昼夜干扰.

关键词:

行为行为行为.在PFAS中,有很多方法.在PFHxS中使用.perfluorohexane 硫酸盐的使用情况一个光周期.斑马鱼是一种斑马鱼.

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