遗传决定的祖先与形态和分子性状腺斑块特征相关
Nima Fahim1, Tim R Sakkers2, Floor B H van der Zalm1
1Central Diagnostic Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Atherosclerosis
|March 6, 2026
概括
遗传祖先影响动脉样硬化斑块的脆弱性和组成. 非欧洲血统显示,具有炎症特征的脆弱斑块的几率更高,影响心血管疾病风险.
科学领域:
- 血管生物学 血管生物学
- 遗传学 是一个遗传学.
- 心血管疾病研究研究
背景情况:
- 动脉样硬化导致心血管疾病 (CVD),而年龄和糖尿病等危险因素并不能完全解释种族差异.
- 在心血管疾病负担中观察到的种族差异,例如冠状动脉化患病率,可能会被自我报告的种族混.
- 基因组知情祖先为研究动脉样硬化的祖先差异提供了更精确的方法.
研究的目的:
- 研究遗传决定的祖先与动脉样硬化斑块的形态和分子特征之间的关联.
- 探索欧洲和非欧洲祖先群体之间的斑块脆弱性和基因表达的差异.
主要方法:
- 从1944年患者的组织学和转录基因数据的分析在阿瑟罗-快速生物库研究.
- 使用主要成分分析与1000个基因组参考小组进行祖先推断.
- 对斑块脆弱性和差异性基因表达分析的顺序逻辑回归.
主要成果:
- 确定了欧洲 (n=1866) 和非欧洲 (n=51) 的祖先群体.
- 非欧洲祖先表现出更高的斑块脆弱性增加的几率 (OR=1.67,p=0.0450).
- 不同的基因表达揭示了NLGN4X和CADM3;通路分析显示了与炎症相关的过程的丰富.
结论:
- 遗传祖先与动脉样硬化斑块的组成和形态相关.
- 非欧洲患者呈现出更炎症,更高风险的斑块特征.
- 在研究中增加祖先多样性对于理解动脉样硬化和开发个性化疗法至关重要.
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