基于生物相容的人造阳离子多糖的多功能载体,与90Y (III) 离子交联,并与内置的抗瘤剂进行交联
M A Orlova1, V V Spiridonov1, A V Gopin1
1Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russian Federation.
概括
新的碳甲基纤维素 (CMC) 微凝作为-90 (Y) 和抗瘤剂的多功能载体. 它们的尺寸和细胞毒性可以根据含量进行调整,在向癌症治疗中具有潜力.
科学领域:
- 放射化学 放射化学是指辐射化学.
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 针对性放射性核酸治疗的开发需要放射性核酸和治疗剂的有效载体.
- 碳氧甲基纤维素 (CMC) 为药物输送应用提供生物相容性和功能性.
研究的目的:
- 合成和描述基于CMC的多功能微凝,用于携带放射性核酸-90 (Y) 和抗瘤剂.
- 研究含量对微凝特性和细胞毒性的影响.
主要方法:
- 通过直接合成和同位素交换合成二进制 (CMC-90Y) 和三进制 (90Y-CMC-effector) 微凝.
- 使用动态光散射 (DLS) 对水力动力直径 (Dh),电泳运动 (EPM) 和红外 (IR) 光谱学进行表征.
- 细胞毒性测试用于评估微凝的生物活性.
主要成果:
- 使用这两种合成方法实现了90Y的最大引入度.
- 发现微凝大小 (Dh) 和电泳性移动性 (EPM) 取决于含量.
- 三元微凝的细胞毒性随伊负载而显著变化,表明结构变化.
结论:
- 基于CMC的微凝是90Y和抗瘤剂的有效多功能平台.
- 含量极大地影响微凝结构,大小和细胞毒性,使可调节的治疗特性成为可能.
- 这些发现支持工程CMC微凝的潜力,用于向的放射性核酸治疗.
相关概念视频
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
67
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
67
01:24Modified-Release Drug Delivery Systems: Site-Targeted
59
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
59