自我报告的情绪相关症状与早期避孕方法中止之间的关联
Bryce Wallis1, Gentry Carter2, Lauren A Gimbel3
1ASCENT Center for Reproductive Health, Department of OB/GYN Family Planning, School of Medicine; Salt Lake City, UT 84112, USA; Department of Molecular Pharmaceutics, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
American journal of obstetrics and gynecology
|March 6, 2026
概括
仅使用孕激素的避孕药的使用者在停止使用这些方法时,报告情绪症状的频率更高. 然而,先前存在的情绪症状与这些方法的更低的断药率有关,显示出复杂的关系.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 避孕药是一种避孕药,用于避孕.
背景情况:
- 关于荷尔蒙避孕药对心理影响的研究结果各不相同.
- 一些研究将荷尔蒙疗法与负面情绪症状联系起来,另一些研究则将情绪改善或没有效果联系起来.
- 了解这些影响对于有效的临床咨询至关重要.
研究的目的:
- 检查自我报告的情绪症状和在六个月内停止避孕药物之间的关联.
- 为了考虑基线情绪症状和避孕方法类型.
- 为了告知临床咨询关于避孕和情绪.
主要方法:
- HER盐湖倡议队列研究的二次分析 (n=4,425).
- 未来3年的随访,在基线,1,3个月和6个月进行调查.
- 混合效应逻辑回归分析了停止治疗的原因,按激素类别分层 (仅孕激素,组合激素,非激素).
主要成果:
- 在6个月内停药的880人中,仅使用孕激素的28%的人表示情绪症状,而21%的组合荷尔蒙和10%的非荷尔蒙使用者 (p<0.001).
- 仅使用孕激素植入体的使用者,与情绪相关的停药率最高 (40%).
- 频繁/每日基线情绪症状下降,仅使用孕激素的方法停止 (OR=0.63),但其他类型没有.
结论:
- 仅使用孕激素的避孕药使用者更频繁地报告情绪症状作为停止治疗的原因.
- 在基线情绪症状负担,方法类型和停止之间存在复杂的相互作用.
- 需要细微的咨询,认识到情绪问题是合法的,并且可能是特定于方法的.
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