在患有抗脂综合征和抗脂抗体消极化的患者中,抗凝停止后的血栓复发:系统性审查和元分析
Linde J Op de Hoek1, Eleonora Camilleri2, Jeroen C J Eikenboom1
1Department of Medicine - Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Journal of thrombosis and haemostasis : JTH
|March 6, 2026
概括
患有抗脂综合征 (APS) 的患者失去抗脂抗体 (aPL) 阳性,在停止抗凝治疗后,血栓复发率较低. 需要进一步的研究来确定aPL负化是否可以指导低风险APS患者的长期抗凝决定.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 抗脂综合征 (APS) 是一种自身免疫性疾病,其特征是血液凝块和抗脂抗体 (aPL) 的存在.
- 长期抗凝药是预防APS中血栓事件的标准.
- 随着时间的推移,aPL阳性丧失的临床影响,特别是关于抗凝剂需求的临床影响,仍然不清楚.
研究的目的:
- 评估在停止抗凝药后对抗脂抗体 (aPL) 呈阴性变化的APS患者中血栓复发的风险.
主要方法:
- 进行了观察性队列研究的系统审查和元分析.
- 搜索的数据库包括Pubmed,Embase,科学网,科克兰图书馆,Emcare和学术搜索总理.
- 主要结局是血栓复发的综合发病率,使用随机效应波桑回归分析.
主要成果:
- 包含55名患者的6项研究符合纳入标准.
- 报告共有3次静脉血栓复发.
- 结合的血栓复发率为每100人年1.61 (95%CI为0.52-4.98).
结论:
- 患有aPL消极化的APS患者的血栓复发率很低,但解释受到数据质量的限制.
- 需要进一步的研究来探索aPL消极化作为重新评估选择低风险APS患者长期抗凝药的因素.
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