确定慢性鼻炎的PM2.5相关炎症内型
Daniel H Lofgren1, Christina Dorismond1, Rory J Lubner1
1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232.
颗粒物 (PM2.5) 暴露与具有特定炎症标记的慢性鼻炎 (CRS) 有关. 这项研究证实了暴露于PM2.5的CRS患者的明显炎症特征,这表明了新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 环境健康 环境健康
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 是一种原因不明的复杂炎症状况.
- 一项先前的研究发现了与微颗粒物 (PM2.5) 暴露相关的CRS中独特的炎症特征.
- 这种特征包括特定细胞因子的粘液水平升高,如IL-2,IL-5,IL-7,IL-12-23p40和IL-21.
研究的目的:
- 为了验证和进一步描述与PM2.5暴露相关的CRS炎症内型.
- 为了研究PM2.5暴露和CRS患者的多变异性细胞因子概况之间的关系.
- 确定空气污染与CRS中的特定免疫反应之间的潜在联系.
主要方法:
- 一个机器学习模型估计了634名CRS患者12个月的每日PM2.5暴露.
- 粘液中细胞因子水平 (IL-2,5,7,13,12-23p40,21) 用细胞计数珠测试进行测量.
- 创建了一个复合细胞因子评分,并分析了与PM2.5水平的相关性,并调整了混因素.
主要成果:
- 较高的估计12个月PM2.5水平显著与复合细胞因子评分的升高有关 (单变分析,p<0.0001).
- 在对年龄,BMI,喘和社会经济地位等临床和社会人口统计因素进行调整后,这种关联仍然存在 (p<0.0001).
- 这些发现支持PM2.5暴露与CRS中的特定炎症特征之间的一致联系.
结论:
- 与PM2.5相关的CRS表现出明显的炎症特征,其特征是特定的粘液细胞因子的多变异性升高.
- 这为CRS中与空气污染相关的2型和3型混合免疫反应内型提供了证据.
- 这些发现强调空气污染是CRS发病的一个重要因素,并建议潜在的内型特异性治疗方法.
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