副甲状腺切除术与保守治疗对原发性甲状腺功能障碍症患者骨矿物质密度的影响
A Green1, K Hardy2, O Al-Dadah3
1Department of General Surgery, South Tyneside District Hospital, Harton Lane, NE34 0PL South Tyneside, United Kingdom.
概括
副甲状腺切除术显著改善了骨矿物质密度 (BMD) 超过医疗管理在原发性副甲状腺症患者超过4年. 手术干预保留了骨质,而医疗治疗导致某些区域的骨质损失.
科学领域:
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 初级甲状腺功能障碍症会导致骨质再吸收和骨质减少.
- 副甲状腺切除术是唯一的治愈治疗方法; 医疗疗法管理症状和骨质疏松症.
- 骨矿物质密度 (BMD) 是高甲状腺症中骨健康的关键指标.
研究的目的:
- 为了比较副甲状腺切除术与医疗管理对 BMD 的影响.
- 为了评估原发性副甲状腺功能障碍症患者的长期骨健康结果.
- 评估手术与非手术治疗对骨密度的疗效.
主要方法:
- 在82名副甲状腺功能障碍患者 (49名手术,33名医疗) 的观察性研究中.
- 用双能X射线吸收计在腰椎,部和前臂评估的BMD.
- 干预前和后的骨质量测量在平均4.3年的随访期间进行了比较.
主要成果:
- 手术组的腰椎 (+6.8%) 和部 (+1.6%) 的骨质量显著增加.
- 医疗组的腰椎骨质量增加 (+3.1%) 但前臂骨质量下降 (-7.1%).
- 手术干预导致所有测量部位的骨质量维护更大,并减少了骨质疏松症/骨质疏松症的发展.
结论:
- 副甲状腺切除术显著改善或保存BMD,比初级副甲状腺症的医疗管理更有效.
- 与非手术方法相比,手术治疗提供了优越的长期骨健康益处.
- 在这两组人群中,改善的BMD可能反映了医疗疗的使用率增加.
关键词:
双酸盐是一种双酸盐.骨矿物质密度 骨矿物质密度石灰模仿剂是指石灰模仿的材料.双能量X射线吸收度测量甲状腺功能障碍症过高症.骨质疏松症是一种骨质疏松症.副甲状腺切除术 (parathyroidectomy) 是一种切除甲状腺的方法.更多相关视频
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