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通过使用零回声时间MRI对异常纠正的跨脊柱聚焦超声波的化物探索

David Martin¹, Meaghan A O'Reilly¹

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C4, Canada.

Ultrasound in medicine & biology

|March 6, 2026

概括

磁共振成像 (MRI) 校正的跨脊柱聚焦超声波 (FUS) 显示出有希望的结果. 准确的脊柱成像对于有效的MRI校正的FUS至关重要,优于未经校正的方法,但不匹配CT校正的聚焦.

科学领域:

医疗成像医学成像
超声波技术超声波技术超声波技术
生物物理学的生物物理.

背景情况:

聚焦超声波 (FUS) 提供了非侵入性的治疗潜力.
通过骨头准确聚焦,就像脊柱一样,由于声学特性变化而具有挑战性.
磁共振成像 (MRI) 指导对于FUS是可取的,但需要准确的声学属性映射.

研究的目的:

以数值评估MRI校正的跨脊柱聚焦超声波 (FUS) 的可行性.
使用CT和MRI衍生的数据,比较不同校正方法的准确性.
为了确定声学属性表示对焦精度的影响.

主要方法:

使用CT和零回声时间 (ZTE) MRI进行了ex vivo胸椎成像.
为了声学属性估计,ZTE图像被转换为伪CT (pCT).
跨脊柱FUS用五种校正策略进行模拟,包括没有校正,pCT校正 (同质/异质) 和CT校正 (同质/异质).
模拟的压力场与CT校正的异质黄金标准进行了评估.

主要成果:

与没有校正相比,MRI校正的聚焦 (pCT) 提高了空间准确性和目标轮相似性.
具有异质性质的pCT校正焦点减少了空间偏移 (1.5 ± 2.0 mm) 并改善了Dice相似性 (0.75 ± 0.10).
同质的CT校正焦点与黄金标准非常接近,空间偏移最小 (0.8±1.7毫米) 和高子相似性 (0.91±0.06).

结论:

通过MRI纠正的跨脊柱FUS是可行的,并且优于未经纠正的方法.
准确的脊柱形态表征对于有效的MR-校正FUS至关重要.
虽然有希望,但目前基于MRI的校正不能完全匹配基于CT对跨脊柱FUS的校正的准确性.

关键词:

聚焦式超声波的使用方法模拟模拟是为了模拟.脊柱脊柱脊柱脊柱脊柱零回声时间零回声时间

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