一个元分析:与结肠直肠癌患者的预后和临床特征相关的表达
Xiaoli Zhang1,2, Huiguang Chen1,2, Qingming Wu1,2
1School of Public Health, Wuhan University of Science and Technology, Wuhan, China.
概括
在10号染色体 (PTEN) 上被删除的酸酶-素同源体的表达在结肠直肠癌 (CRC) 组织中较低. 阳性PTEN表达与更好的生存相关,表明其作为CRC的预后标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 结肠直肠癌 (CRC) 的发病率和死亡率在全球范围内不断增加.
- 在瘤发生过程中观察到酸酶-素同类素在第10染色体上被删除 (PTEN) 的失调.
- 在CRC中PTEN的预后意义需要进一步澄清.
研究的目的:
- 评估PTEN表达和CRC临床病理特征之间的关联.
- 为了确定结直肠癌患者PTEN表达的预后值.
- 通过元分析来综合现有证据.
主要方法:
- 在主要科学数据库 (Web of Science,PubMed,Cochrane Library,CNKI) 进行的系统文献审查,截至2023年6月.
- 包括13项研究,共包括2377名参与者.
- 进行元分析,以评估PTEN表达和CRC预后之间的相关性.
主要成果:
- 与正常的邻近粘膜相比,PTEN表达在CRC组织中显著降低.
- 阳性PTEN表达与改善CRC患者的整体存活率和有利的病理特征有关.
- 在PTEN表达和年龄,性别,分化度,瘤大小或远程转移之间没有发现显著的关联.
结论:
- 负的PTEN表达是结直肠癌的不良预后指标.
- PTEN表达水平可以作为监测CRC疾病进展和预测患者结果的有价值的生物标志物.
- 对PTEN作用的进一步研究可以为治疗策略和患者管理提供信息.
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