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Updated: Mar 8, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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通过SRCAP和H2A.Z调节基因的机制

Armelle Tollenaere1, Enes Ugur2,3, Susanna Dalla Longa4

  • 1Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Institute of Bioengineering, Lausanne, Switzerland. armelle.tollenaere@epfl.ch.

Nature communications
|March 6, 2026
PubMed
概括

与Snf2相关的CREBBP激活蛋白 (SRCAP) 改造器抑制了独立于H2A.Z的转录因子结合,而H2A.Z抑制了谱系特定的基因,保持了干细胞自我更新.

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