特雷霍洛斯通过调节肠道微生物代谢来改善严重的急性胰腺炎
Haibin Hao1, Deren Du1, Hong Lin2
1Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
NPJ biofilms and microbiomes
|March 6, 2026
概括
治疗Trehalose可以通过恢复肠道微生物代谢来缓解严重的急性胰腺炎 (SAP). 这种糖促进碳水化合物代谢,减少脂质代谢,改善胰腺损伤和肠-胰腺轴通信.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 严重急性胰腺炎 (SAP) 的特征是肠道微生物失调和代谢失衡.
- 肠道微生物群的变化显著影响SAP的发病和进展.
研究的目的:
- 调查三糖在SAP中调节肠道微生物群代谢中的作用.
- 通过准肠-胰腺轴,探索特雷荷对SAP的治疗潜力.
主要方法:
- 在SAP模型中分析肠道微生物代谢.
- 评估糖治疗对胰腺损伤和微生物组成的影响.
- 研究特雷荷对血清炎症标志物和亡途径的影响.
主要成果:
- SAP诱导了肠道微生物的代谢失衡,脂质增加和碳水化合物/氨基酸代谢减少.
- 糖治疗逆转了这些代谢变化,减少了胰腺损伤,并调节了像Muribaculaceae这样的特定肠道细菌.
- 特雷荷抑制了SAP诱导的炎症 (IL-6,IL-17A,TNF-α),降低了甘油三 (TG),抑制了亡,并减少了巨细胞透.
结论:
- 醇可以通过恢复肠道微生物代谢的恒常性来改善SAP.
- 特雷哈洛斯的治疗效果是通过肠道微生物群调节来调节的,突出了微生物代谢-肠道-胰腺轴.
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