关于白质微观结构与精神分裂症患者的积极和消极症状严重程度之间的关系的ENIGMA联盟研究
Aoife Warren1, Laurena Holleran1, Ingrid Agartz2
1School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.
Schizophrenia (Heidelberg, Germany)
|March 6, 2026
概括
精神分裂症症状严重程度与白质变化有关,特别是在时间区域的积极症状. 在考虑疾病持续时间后,负面症状显示与前额白质有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症症状的严重程度与灰质体积的减少有关.
- 在精神分裂症中已知白质微观结构的改变,但它们与症状严重程度的联系尚不清楚.
- 研究中的方法差异可能解释了不一致的发现.
研究的目的:
- 通过使用标准化方法,研究精神分裂症症状严重程度与白质微观结构之间的关联.
- 测试积极症状是否与时间白质变化相关,负症状是否与前额白质变化相关.
- 探索疾病持续时间和抗精神病药物的使用是否解释了研究结果的异质性.
主要方法:
- 对白质微观结构和来自19个地点的1025名个体的症状严重程度数据的元分析.
- 使用来自ENIGMA联盟的标准化微分异构 (FA) 分析管道.
- 检查了症状严重程度 (阳性和阴性) 和区域/全球FA之间的关联,考虑到疾病持续时间和抗精神病药物的使用.
主要成果:
- 阳性症状严重程度与叶和全球FA显著相关.
- 消极症状的严重程度最初没有显示出与正面或全球FA有显著的关联,异质性由疾病持续时间解释.
- 在删除一个异常点后的特例分析显示,负症状严重程度和全球和正面FA之间存在显著的关联.
结论:
- 精神分裂症的特征是与临床症状严重程度相关的大脑连接受损.
- 积极的症状与广泛的白质变化有关,特别是在部区域.
- 负面症状也与白质完整性有关,特别是在额头区域,强调了脑连接在精神分裂症病理生理学中的作用.
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