一种基于营养风险指数的诺莫图谱,用于预测预后,并确定鼻癌的诱导化疗受益者
Sunqin Cai1, Jue Wang2, Ying Li2
1Department of Radiation Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Scientific reports
|March 6, 2026
概括
营养风险指数 (NRI) 是鼻癌 (NPC) 患者可靠的预后指标,有助于个性化治疗选择. 高NRI预测更好的生存结果,并指导治疗选择.
科学领域:
- 在瘤学瘤学.
- 医疗营养治疗 治疗 治疗
背景情况:
- 鼻癌 (NPC) 的预后受到各种因素的影响.
- 确定可靠的预后指标对于优化患者管理和治疗策略至关重要.
研究的目的:
- 评估鼻癌 (NPC) 患者营养风险指数 (NRI) 的预后意义.
- 开发和验证NPC中风险分层和个性化治疗选择的名录.
主要方法:
- 一项双中心研究招募了1174名NPC患者.
- 卡普兰-梅尔分析和多变量考克斯回归确定了预后因素.
- 使用决策曲线分析 (DCA) 和校准曲线构建和验证了一个预测性名图.
主要成果:
- 与低NRI (<112.11) 患者相比,高NRI (≥112.11) 的患者显示出明显更好的生存结果.
- NRI是远程转移无存活率,整体存活率 (OS) 和局部区域无复发存活率的独立预后因素.
- 诺米图表表现出强大的区分能力 (C指数:0.715培训,0.678验证) 和良好的校准,通过DCA.通过优异的临床净益.
- 低风险患者的3年生存率 (97.8%) 和无进展生存率 (PFS, 93.0%) 比高风险患者 (OS 81.1%,PFS 69.3%) 高得多.
- 在高危NPC患者中,诱导化疗 (IC) 加放射治疗 (RT) /并发化疗放射治疗 (CCRT) 与单独RT/CCRT相比,改善了OS和PFS.
结论:
- 营养风险指数 (NRI) 是鼻癌 (NPC) 的可靠预后指标.
- 开发的诺米图有效地分层患者的风险,并支持NPC的个性化治疗决策.
- 这些发现表明,治疗强化可能有利于由NRI识别的高风险NPC患者.
更多相关视频
相关概念视频
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
1.4K
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
1.4K
Enteral Nutrition I: Orogastric and Nasogastric Feeding
2.0K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
2.0K
Dosage Regimen Designs: Nomograms and Tabulations
264
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
264
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
701
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
701
Cancer Survival Analysis
807
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
807


