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Updated: Mar 8, 2026

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依赖HMGCS2的β-OHB/H3K9bhb改善了阿尔茨海默病中的突触可塑性和认知能力

Haitao Yu1,2, Fangzhou Wang3, Jia-Qi Yuan3

  • 1Department of Fundamental Medicine, Wuxi School of Medicine, Jiangnan University; MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, School of Medicine, Jiangnan University, Wuxi, People's Republic of China. yu_haitao@jiangnan.edu.cn.

Experimental & molecular medicine
|March 6, 2026
PubMed
概括

性饮食通过基因素修饰改善阿尔茨海默氏症 (AD) 的认知能力. 通过HMGCS2上调调节恢复β-基酸盐 (β-OHB) 和H3K9bhb水平,可以提高AD模型中的突触可塑性和认知功能.

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